Dynamics of Histaminopexia and Serotoninopexia in Neurodermatis
Patients During Ozone Therapy
O. Bitkina.
Nizhny Novgorod State Medical Academy, Russia.
It is known that small doses of ozone lead to selective oxidation
of the aminoacids. Sulfur contained and aromatic aminoacids are
most sensitive to ozone activity. Particularly during ozone
influence histidine (predecessor of histamine) level is
decreasing. The increase of biogenous amines in the acute stage
with heritable deficit of the plasmopexic fractions
(histaminopexia and serotoninopexia). Ozone therapy by means of
minor autohemo-ozone therapy and rectal insuflactions was used for
treating 60 neurodermatitis patients, 27 male and 33 female
persons. Patients were from 9 to 35 years of age, 21.8 years in
average. The disease lasted from 1 to 35 years ((18.7 years in
average). The study of histaminopexic index (HPI) and
serotoninopexic index (SPI) was made before ozone therapy course,
the 2nd test was performed in 10 to 14 days of monoozone therapy
and the 3rd test after the complex treatment which included
traditional aids. 32 patients (53 %) demonstrated clinical
remission, 27 (45 %) significant improvement and 1 patients (2 %)
had small improvement. Initial HPI level is not significant high
than control group data (19.49 ± 7.04 %, the normal is 16.4 ± 1.1
%). After 10-14 days of the monoozone therapy, HPI was increased
to 30.33 ± 7.12 %. After the treatment HPI was decreased to 9.86 ±
3.69 %. Initial SPI level was 19.84 ± 1.59 % (the normal is 21.2
±2.8 %). In neurodermatitis, complicated by eczema, SPI level
(13.49 ± 2.33 %) was significantly lower than in general group
data (p-0.05). After 10-14 days of the monoozone therapy SPI was
increased to 21.12 ± 1.59 %. After the complex treatment SPI was
decreased to 18.26 ± 1.29 %. Generally SPI dynamics was like to
HPI activity changes. During ozone treatment histaminopexic and
serotoninopexic plasma activity increased. Decrease of that data
after the treatment may be explained by elimination of connected
histamine and serotonine from organism.
Source: 2nd International Symposium on Ozone Applications
Havana, Cuba – Mach 24-26, 1997.
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