AU  - Ceccherelli F
AU  - Gagliardi G
AU  - Faggian L
AU  - Loprete F
AU  - Giron G

TI  - Analgesic effect of subcutaneous administration of oxygen-
      ozone. A blind study in the rat on the modulation of the 
      capsaicin-induced edema.

AB  - The Authors have explored a new complementary approach,
      employed in the last 40 years for, among other uses, medical 
      purposes: oxygen-ozone therapy. Anecdotal works have highlighted 
      interesting results obtained in disk herniation with infiltration 
      of paravertebral muscles with oxygen-ozone. To verify the 
      existence of a nociceptive effect and investigate a possible 
      mechanism of action, an experimental model of edema induction 
      by subcutaneous capsaicin injection in the rat paw was 
      employed. Oxygen-ozone, in different concentrations (10 
      microg/ml, 20 microg/ml and 30 microg/ml) has been injected 
      both ipsi- and contralaterally to the paw 30 minutes before 
      the administration of 50 microg capsaicin in 50 microl 
      of physiological solution. Results show that the contralateral 
      injection of the O2-O3 mixture modulates the edema response 
      in the paw. Statistical significance, for the 20 microg/
      ml mixture, lasts as far as 45 minutes after administration 
      of the capsaicin. No efficacy has been found for the 10 
      and 30 microg/ml concentrations. An injection of the same 
      quantity of gas in the ipsilateral paw to the capsaicin-
      induced edema determines a worse edema than that observed 
      in the control group, as if the ozone mixture added its 
      irritative effect to that of capsaicin. It is interesting 
      to note that the administration of oxygen alone cause a 
      greater edema than the oxygen-ozone mixture.

MH  - Acupuncture Analgesia|*
MH  - Edema|CI/*PC
MH  - Neurogenic Inflammation|CI/*PC
MH  - Oxygen|*AD/AE
MH  - Ozone|*AD
SO  - Acupunct Electrother Res 1998; 23(3-4):171-84
DP  - 1998
TA  - Acupunct Electrother Res
PG  - 171-84
IP  - 3-4
VI  - 23
UI  - 99208045