OxyFile #162

Comparison of effects on tissue oxygenation of hyperbaric oxygen and 
intravascular hydrogen peroxide

Surgery, Vol. 63, No. 2, pp. 285-290

NORMAN B. ACKERMAN, M.D., Ph.D. 
FLOYD B. BRINKLEY, B.S.
Boston, Mass.
From the Department of Surgery, Boston University, Medical Center, and 
Chemical Research and Development Laboratories, Edgewood Arsenal

Abstract:

There are numerous pathologic conditions that are related to, or 
caused by a decrease in tissue oxygenation. These conditions include 
many cardiovascular and pulmonary diseases, as well as certain 
infectious and toxic states. During the past few years there has been 
considerable interest in the experimental use of both hyperbaric 
oxygen (OHP) and intravascular hydrogen peroxide (H2O2) as techniques 
for improving tissue oxygenation. Although the mechanisms of action 
are different, both OHP and H2O2, are effective in increasing tissue 
oxygen tensions. The present study was designed to compare the 
effectiveness of these 2 techniques.