OxyFile #72

TI:  Rationale For Treatment of Cancer with Ozone

DT:  1988

AU:  Boguslaw Lipinski, Ph.D.

SO:  Boston Cardiovascular Health Center and Tufts University 
     School of Medicine 	One Washington Street, Wellesley, MA. 
     02181

AB:  The hypothesis is presented according to which cellular 
     aging and divisions are controlled by the levels of oxygen 
     and natural antioxidants (AOs).  Normal homeostasis is 
     characterized by optimal concentration of both factors.  In 
     cancer there is an abnormally high concentration of 
     artificial, food-derived AOs and low oxygen supply.  Under 
     such conditions there is no lipid peroxidation products 
     formed and thus no inhibitors are present to control cell 
     division.  This situation, similar to that occurring in the 
     anaerobic cells can be reversed by introduction of strong 
     oxidants such as oxygen or ozone in the presence of 
     sufficient concentration of natural antioxidants (vitamin C 
     and E).  Intraarterial administration of ozone might, 
     therefore, prove to be an effective treatment for many types 
     of cancer.