Ozonation of 5-Fluoroacil and Citarabine in Aqueous Medium
A.S. Padrón, M.E. Martínez, L. García, R. Pérez-Rey(1), C.
Drug Development and Research Center, Cuba.
1 – Ozone Research Center, Cuba.
Wastewaters from pharmaceutical manufactures of citostatic drugs
are, in principle, polluted with them. These compounds can result,
under certain circumstances, toxic and even carcinogenics. The
problem of removing such compounds from water has not been
completely solved yet. This work comprises the ozone inactivation
of 5-fluoroacil and citarabine, two nitrogen bases with citostatic
properties dissolved in water. Results show that both compounds
can be inactivated by ozonation. The composition of the reaction
mixture was followed by HPLC and at the end of the reaction, the
Ames test performed showed that the reaction products resulted non
Source: 2nd International Symposium on Ozone Applications
Havana, Cuba – Mach 24-26, 1997.