Urinary Organic Acid Profile of Rats Treated Orally with Oleozon
D. Jardines, Z. Zamora, T. Correa1, A. Rosado(1), J. Molerio.
Ozone Research Center, Cuba.
1 – National Scientific Research Center, Cuba.
The OLEOZON (ozonized sunflower oil) is a drug produced in the
Ozone Research Center. Taking into account its great germicidal
power, it is very useful in the treatment of bucal illness
(gingivostomatitis), skin lesions and in the giardiasis. The main
products in the ozonolysis of sunflower oil are hydroxycompounds
and acids that can be found in different biological fluids. The
study of biological fluid chromatography profiles can give us new
information about the biochemical reactions that take place in the
organism. The aim of this work is to study the organic acid
excretion in urine of rats treated with OLEOZON using the gas
chromatography/mass spectrometry tectonics. Significant
differences (p<0.01) respect to the organic acid excretion in urine of rat without treatment were found. increased amounts of dicarboxylic acids are pimelic, azelaic and octenedioic. azelaic acid is recognized as anti-comedogenic and anti viral agent, also antifibrinolytic in melanoma cell cancer. it is possible that this acid would be one of the active principles of the oleozon. further research will be necessary to prove this hypothesis. source: 2nd international symposium on ozone applications havana, cuba - mach 24-26, 1997.