Total Ozone Therapy of Trophic Ulcers of Lower Extremities in
S. Gorbunov, L. Gorbunova, Ph. Romashov, V. Dmitriev, V. Isaev.
Medical Institute Of Frontier-Guard Service, The Medical Academy,
Nizhni Novgorod, Russia.
Trophic ulcers of foot and crus are known to be a common pathology
among elderly patients causing frequent loss of working capacity
and disability, requiring a long course of treatment and having a
tendency to recurrence. The available current methods of treatment
do not appear to be sufficient and effective enough. It gives rise
to a search of new methods for their treatment. Local complex
treatment, aimed a sanatory and stimulation of spontaneous
epithelization, seems to be more appropriate for patients of
elderly and gerontal age, having a lot of accompanied diseases.
Hence, current treatment principles should be based on agents with
marked antibacterial properties and simultaneously able to
eliminate local hypoxia and regulate oxygen dependent processes.
Medical ozone meets all these requirements. Regarding its medical
properties, ozone has been used in the complex treatment of 42
patients with long-term trophic ulcers of foot and crus (age range
61-8~ years). Complex ozone therapy included local effect of
gaseous ozone in plastic sac. Besides, for the first 8-10 days the
ulcer was covered with ozone saturated antiseptic dressing. With
the signs of marked epithelization, antiseptic dressing were
substituted by the ones with ozonated olive oil. Ulcers with pyo-
necrotic deposit were covered with ozonated enterosorbents for the
first 3-5 days. Along with external treatment in plastic sacs, the
surrounding surface of ulcer was subcutaneously injected with
ozone/oxygen mixture. With the aim of detoxication, as well as
normalization of oxygen-dependent processes and improvement of
microcirculation, all the patients received intravenous injections
of 250.0 mL ozonated rheopolyglukine, daily. The most efficient
was found to be a complex treatment of vulnerosorbtion with press
vacuum external ozone therapy in hard-frame chamber. By the 10 12
day of treatment the ulcer surface became sterile, epithelization
rate being not more than 4-5 % a day, starting from the third week
it reached 11-12 % a day. Only one patient, out of 42, did not
have a complete cover of ulcerative defect in skin surface.
Source: 2nd International Symposium on Ozone Applications
Havana, Cuba – Mach 24-26, 1997.