Ozone Influence on Pro-Inflammatory Process in Maxillo-Facial Part
of Head and Neck
E. Durnovo, I. Kinyapina, C. Kontorschikova.
The Medical Academy of Nizhni Novgorod, Russia.
The results of ozone therapy combined with traditional treatment
of 50 patients with odontogenic maxillofacial phlegmons are
presented. Ozone was used in concentrations of 1300 g/L for
intravenous injections of ozonated saline and in concentration of
4500 g/L and 2000 g/L for local dialysis of wounds and mouthwash
with ozonated distilled water. A special group consisted of
patients with severe saprogenous necrotic phlegmons. The lesions
involved the neck and mediastinal organs. The surgical management
of such patients often includes tracheostoma and dissection of
mandibular muscles to provide a better wound drainage. The use of
ozone resulted in wound clearance from purulent exudate and
necrosis on the 3-4 day. The wound was shown to have activation of
mononuclear phagocytes, reinforcement of mesenchymal proliferation
with parallel intensive development of epithelium covering the
wound surface. Starting from the first ozonated intravenous
procedure the patients showed improvement in general condition,
normalization of body temperature and laboratory blood data,
activation of general antioxidant system and local immune
resistance of oral cavity. As a result secondary sutures could be
done on 7-8 day and in some cases even to suture the wounds
completely. It helped to avoid disfiguring scars formation.
Source: 2nd International Symposium on Ozone Applications
Havana, Cuba – Mach 24-26, 1997.