Hydrogen peroxide cream: an alternative to topical antibiotics
in the treatment of impetigo contagiosa.
Author: Christensen OB; Anehus S
Source: Acta Derm Venereol 1994 Nov; 74(6):460-2
In total, 256 patients with bacteriologically verified
impetigo contagiosa were included in three double-blind,
parallel group, randomized, multi-centre trials, where
the efficacy of hydrogen peroxide cream (Microcid) was
compared with that of fusidic acid cream/gel (Fucidin).
The trials were performed at 47 centres in three countries,
Sweden, Germany and UK, and the results are compiled in
the present report. During the course of the 3-week treatment
period, 92 patients out of 128 (72%) in the Microcid group
were classified as healed, compared to 105 patients out
of 128 (82%) in the Fucidin group. This difference was
not statistically significant. The reduction in composite
sign severity score (the sum of the score for erythema,
vesiculation/bullae, weeping and crusting divided by four)
in each separate study was 73%, 78% and 84% in the Microcid
group and 85%, 85% and 84% in the Fucidin group. No statistically
significant differences were found in the separate studies
or when compiling the studies in a meta-analysis. When
the patients had been classified as healed, beta-haemolytic
streptococci were eliminated in all patients treated with
Microcid cream. Since treatment started before the result
of the bacteriology was known, another 135 patients with
negative skin culture were enrolled in the trials, i.e.
391 patients were included in the safety analysis. Out
of these, 23 patients reported the occurrence of adverse
events, mainly classified as mild. In conclusion, Microcid
cream has been documented as a topical alternative to fusidic
acid in the treatment of impetigo.