OxyFile #50

TI:   The Use of Ozone-Treated Blood in the Therapy of HIV 
      Infection and Immune Disease:  A Pilot Study of Safety and 
      Efficiacy

DT:   1991

AU:   Gary E. Garber, D. William Cameron, Nanci Hawley-Foss, 
      Donald Greenway, and Michael E. Shannon

SO:   AIDS 1991, 5:981-984

AB:   The use of ozone therapy is reported to be effective in a 
      variety of viral illnesses, including HIV disease.  We 
      performed a phase 1 study of ozone blood treatments in 10 
      patients in whom no significant toxicity was observed.  
      Three patients with moderate immunodeficiency showed 
      improvement in surrogate markers of HIV-associated immune 
      disease.  A phase 2 controlled and randomized double-
      blinded study was initiated comparing reinjection of ozone-
      treated blood, and reinjection of unprocessed blood for 8 
      weeks, followed by a 4-week observation period.  Ozone had 
      no significant effect on hematologic, biochemical or 
      clinical toxicity when compared with placebo.  CD4 cell 
      count, interleukin-2, -interferon, 2-microglobulin, 
      neopterin and p24 antigen were also unaffected by both 
      treatment arms.  In conclusion, ozone therapy does not 
      enhance parameters of immune activation nor does it 
      diminish measureable p24 antigen in HIV-infected 
      individuals.

Note: It would wise to speak to Dr. Michael Shannon, Director 
      Medical Operations, Canadian National Defence before you 
      put too much weight on this study.  In Ed McCabe's 
      "Chronological Ozone Medical References" and "O3 vs AIDS", 
      Mr. McCabe wrote, "Poorly designed because the study only 
      gave 10 cc's of ozone into a muscle (dismissed by Aubourg 
      in 1938 as too painful and ineffective), not I.V., and not 
      enough to do any good, and not for long enough time 
      period."  "Poorly executed because during the second half 
      of the too short study, the principals admitted the ozone 
      machine had broken, and wasn't producing any ozone, yet 
      they ignored this fact when they wrote up the second phase 
      of the study!"